ISO 22716 · GMP · CE · Anti-Oxidation N2 Filling
Cosmetic Serum Ampoule Filling Machine — Anti-Oxidation Filling for Serums, Hyaluronic Acid & Active Skincare
Precision cosmetic filling machine engineered for premium single-dose serum ampoules — facial serums, hyaluronic acid, vitamin C, peptides, and ampoule treatments. Nitrogen-blanket anti-oxidation filling protects active ingredients, ±1.0% dosing accuracy preserves your formula cost, and full ISO 22716 cosmetic GMP documentation supports export to the EU, US, and global markets.
60-200/min
Output Range
±1.0%
Fill Accuracy
1-30ml
Fill Range
316L
Contact Parts
ISO 22716 Cosmetic GMP
N2 Anti-Oxidation
Hyaluronic Acid Ready
EU/US Export Ready
For active serums, the biggest hidden loss isn't the machine — it's oxidized vitamin C and degraded actives. A proper nitrogen-blanket fill pays for itself within months on formula savings alone.
— Forester Xiang, Founder & Chief Engineer
Anti-Oxidation
N2 Blanket Fill
Cosmetic GMP
ISO 22716
Cosmetic Serum Ampoule Filling Machine — Quick Reference
A cosmetic serum ampoule filling machine is a precision filling and sealing machine that doses skincare serums, hyaluronic acid, and active treatments into single-dose ampoules or vials. It uses peristaltic or piston pumps for ±1.0% accuracy, optional nitrogen-blanket filling to prevent oxidation of sensitive actives, and is built to ISO 22716 cosmetic GMP for facial serums, ampoule treatments, and premium skincare.
Capacity: 60–200 ampoules/min
Fill range: 1–30ml per ampoule
Fill accuracy: ±1.0%
Pump options: peristaltic / piston / ceramic
Anti-oxidation: optional N2 blanket fill
Contact parts: SUS 316L (cosmetic GMP)
Containers: glass/plastic ampoules, vials, droppers
Compliance: ISO 22716, GMP, CE
Best for: facial serums, hyaluronic acid, vitamin C, peptides, ampoule treatments, essential oils
Source: HIJ Machinery (Wenzhou), HIJ-CS Series cosmetic serum ampoule filling machine specifications. Verified by Forester Xiang, Founder & Chief Engineer (20+ years, 100+ pharmaceutical & cosmetic facility audits).
The Skincare Advantage
Why Single-Dose Ampoule Filling Wins for Active Serums
Vitamin C, retinol, and hyaluronic acid degrade the moment they meet oxygen and light. Single-dose ampoule filling with nitrogen protection keeps every active at full potency — which is exactly why premium K-beauty and clinical skincare brands package serums this way.
Protects Active Ingredients
Nitrogen-blanket filling displaces oxygen, preventing the oxidation that browns vitamin C and degrades retinol.
Premium Brand Positioning
Single-dose ampoules signal luxury, freshness, and clinical precision — commanding higher retail prices.
No Formula Waste
±1.0% accuracy on expensive actives (peptides, growth factors) directly protects your margin on every fill.
No Preservative Pressure
Sealed single doses reduce contamination risk — enabling cleaner, preservative-light "clean beauty" formulas.
A Korean serum brand I worked with in 2024 was losing nearly 8% of their vitamin C ampoules to oxidation browning before the product even hit shelves. Adding an inline nitrogen-purge module on the filling station dropped their reject rate below 1% and extended shelf life by 6 months. For high-value actives, anti-oxidation filling isn't optional — it's the whole point.
— Forester Xiang, Founder & Chief Engineer, HIJ Machinery
Technical Sheet
Cosmetic Serum Ampoule Filling Machine — Specifications
Cosmetic-GMP engineering built for precise, oxidation-free serum and hyaluronic acid production.
HIJ-CS Series Cosmetic Serum Ampoule Filling Machine — Specifications
| Parameter | HIJ-CS Series | What This Means For You |
|---|---|---|
| Capacity | 60–200 ampoules/min | Scale from boutique serum brands to high-volume contract manufacturing on one platform. |
| Fill Volume | 1ml – 30ml | Covers 2ml ampoule treatments to 30ml serum bottles — one machine, your full SKU range. |
| Filling Accuracy | ±1.0% | Protects margin on costly actives — peptides, growth factors, retinol — with zero overfill waste. |
| Pump Type | Peristaltic / Piston / Ceramic | Matched to viscosity — watery serums, thick hyaluronic gels, or oil-based facial oils. |
| Anti-Oxidation | Optional N2 nitrogen purge | Pre & post nitrogen blanket protects vitamin C, retinol, and other oxygen-sensitive actives. |
| Control System | Siemens PLC + HMI Touchscreen | Recipe storage for multiple serum SKUs, fast changeover, low operator training cost. |
| Contact Material | SUS 316L Stainless Steel | Inert, cosmetic-GMP contact surfaces — no reaction with active or acidic serum formulas. |
| Compliance | ISO 22716 · GMP · CE | Cosmetic GMP documentation ready for EU CPNP and US FDA cosmetic export markets. |
Building a Serum or Ampoule Line?
Tell us your serum type, viscosity, fill volume, and target output — we'll return a custom spec + ISO 22716 documentation within 24 hours.
Get Free Custom Quote
Applications
What This Cosmetic Filling Machine Handles
From clinical hyaluronic acid ampoules to luxury facial oils — one filling platform, configured for your formula's viscosity and sensitivity.
Active Serums
Vitamin C serums
Retinol serums
Peptide serums
Niacinamide solutions
Hydration & Gels
Hyaluronic acid (high viscosity)
Essence ampoules
Hydrating boosters
Gel ampoule treatments
Oils & Specialty
Facial oils & essential oils
Hair growth serums
Eyelash/brow serums
Sample/trial ampoules
Frequently Asked Questions
Cosmetic Serum Ampoule Filling Machine — FAQ
Real questions from skincare brands and contract manufacturers — answered by our engineering team.
What is a cosmetic serum ampoule filling machine?
A cosmetic serum ampoule filling machine is a precision filling and sealing machine that doses skincare serums, hyaluronic acid, and active treatments into single-dose ampoules or vials. It uses peristaltic or piston pumps for ±1.0% accuracy, offers optional nitrogen-blanket filling to prevent oxidation of sensitive actives like vitamin C and retinol, and is built to ISO 22716 cosmetic GMP standards.
How much does a cosmetic serum filling machine cost?
The HIJ-CS Series cosmetic serum ampoule filling machine is priced in the $22,000–$58,000 USD range, depending on filling heads, pump type, nitrogen anti-oxidation module, capping/dropper station, and vision inspection. This is 50–60% less than equivalent European cosmetic fillers while using Siemens PLC. A free custom quote is provided within 24 hours.
Can it fill thick hyaluronic acid and gel serums?
Yes. We select the pump based on your formula's viscosity — peristaltic pumps for thin watery serums, and piston or ceramic pumps for thick hyaluronic acid gels and viscous essences. The system maintains ±1.0% accuracy even with high-viscosity products. Just send us a sample spec and we'll recommend the right configuration.
How does the nitrogen anti-oxidation filling work?
The optional nitrogen (N2) module purges oxygen from the ampoule before and after filling, creating an inert nitrogen blanket over the serum. This prevents the oxidation that browns vitamin C, degrades retinol, and shortens shelf life. In practice it can reduce oxidation-related rejects from 8% to under 1% and extend shelf life by several months — critical for high-value active serums.
Is the machine ISO 22716 compliant for cosmetic export?
Yes. All product contact parts use SUS 316L stainless steel, and the machine is built to ISO 22716 cosmetic GMP and CE standards. We provide documentation to support EU CPNP registration and US FDA cosmetic requirements, helping you export serums to the EU, US, and global markets with confidence.
Do you provide installation and training worldwide?
Yes. HIJ dispatches engineers to over 50 countries for installation, commissioning, and operator training (typically arriving 7–10 days after delivery). We also provide 24/7 remote diagnostics via secure VPN in 5 languages, plus a 2-year mechanical warranty and 5-year guaranteed spare parts availability.
Still Have Questions About Your Serum Line?
Our engineering team responds to technical inquiries within 24 hours with detailed answers tailored to your serum formula and target market.
Get Free Custom QuoteAbout HIJ Machinery
HIJ Machinery (Wenzhou) is a pharmaceutical and cosmetic packaging machinery manufacturer founded in Wenzhou, China. The company produces cosmetic serum ampoule filling machines, cream tube filling sealing machines, prefilled syringe filling machines, and complete turnkey cosmetic packaging lines. All equipment is CE certified and built to ISO 22716, WHO GMP, cGMP, and 21 CFR Part 11 standards. Founder Forester Xiang has 20+ years of packaging machinery experience and has personally audited 100+ pharmaceutical and cosmetic facilities across 30+ countries.