HIJ-DZA100
Plastic Syringe Filling and Capping
1 needle1,800–2,100 p/h
For liquid or ointment filling into nominated plastic syringe and cap formats. The source document lists a 0.5–50 ml range and 3 kW total power.
Plastic capping and SCF glass stoppering platforms
Syringe Filling Machines for Plastic and Glass Prefilled Syringes
Compare four HIJ syringe filling machine platforms by syringe system, closure method, filling needles and published output. Final selection is based on your formulation, components, format range, cleanroom boundary and FAT acceptance method.
01Plastic syringe filling and capping: HIJ-DZA100 or two-needle HIJ-DZA200.
02SCF glass syringe vacuum filling and stoppering: HIJ-GZB100 or two-needle HIJ-GZB200.
03Quotation basis: actual product, syringe, closure, accepted output and agreed test protocol.
4 machine platformsTwo closure routes and one or two filling needles
600–3,900 p/hPublished model range, not a project guarantee
≤±1–2%Source-document reference; define the test method
Four model routes
Choose the syringe filling machine by component and closure
The first decision is whether the project uses a plastic syringe and cap or an SCF glass syringe and stopper. The second is whether one or two filling needles are justified by the required accepted output and product trial.
HIJ-DZA200
Double-Head Plastic Syringe Filler
2 needles3,000–3,900 p/h
For a higher published output on compatible plastic syringe projects. The source document lists 1–50 ml, with mold or pump changes required for some formats and dose ranges.
HIJ-GZB100
Vacuum Filling and Stoppering
1 needle600–800 p/h
For nominated SCF glass syringe and stopper formats. The source document lists grouped manual loading, automatic filling, vacuum stoppering and automatic discharge.
HIJ-GZB200
Double-Head Vacuum Filler
2 needles800–1,200 p/h
Two-needle vacuum filling and stoppering for confirmed SCF glass syringe formats. The source document lists 3 kW total power and an optional automatic nest remover.
Published technical references
Compare HIJ syringe filling machine specifications
These values come from the four named product documents and apply to the listed platform only. They are screening references. The approved proposal must identify the actual product, components, utilities, options and test conditions.
| Model | Syringe and closure route | Published sizes | Needles | Published capacity | Accuracy reference | Total power |
|---|---|---|---|---|---|---|
| HIJ-DZA100 | Plastic syringe filling and capping | 0.5–50 ml | 1 | 1,800–2,100 p/h | ≤±1–2% | 3 kW |
| HIJ-DZA200 | Plastic syringe filling and capping | 1–50 ml; mold and pump range must be confirmed | 2 | 3,000–3,900 p/h | ≤±1–2% | 8.5 kW |
| HIJ-GZB100 | SCF glass syringe vacuum filling and stoppering | 0.5, 1, 2.25, 3, 5, 10 and 20 ml; not universal | 1 | 600–800 p/h | ≤±1–2% | 2.5 kW |
| HIJ-GZB200 | SCF glass syringe vacuum filling and stoppering | 0.5, 1, 2.25, 3, 5, 10 and 20 ml; not universal | 2 | 800–1,200 p/h | ±1–2% | 3 kW |
Do not compare speed alone. Published capacity is not the same as accepted units per hour. Actual output can change with fill volume, product behavior, syringe presentation, closure feeding, inspection, rejection, operator intervention and the agreed operating window.
Selection logic
Which syringe filling machine fits your project?
Use the component path first. A plastic syringe cap and an SCF glass syringe stopper need different handling, feeding and closure systems. Needle count comes after the process route has been fixed.
Choose between DZA100 and DZA200
Use this route when the required process is quantitative filling followed by plastic cap feeding and capping. DZA100 is the one-needle reference. DZA200 is the two-needle reference for a higher published throughput.
- Provide the syringe and cap drawings and production samples
- Confirm liquid or ointment and the full fill-volume range
- Identify which formats need separate molds or pump assemblies
- Define cap presence, capping position and reject criteria
Choose between GZB100 and GZB200
Use this route when the nominated SCF glass syringe and elastomeric stopper require filling and vacuum stoppering. GZB100 uses one filling needle; GZB200 uses two.
- Provide tub, nest, syringe and stopper identification and drawings
- State whether grouped manual loading or automatic denesting is required
- Define the visible-air and stopper-position acceptance method
- Confirm discharge, rod insertion and labeling interfaces
Important scope boundary: the source documents describe optional local laminar-flow hoods. That option alone does not establish an aseptic process or a validated sterile product. The buyer must define the facility, environmental classification, contamination-control strategy, component preparation, monitoring, qualification and operating procedures.
Machine process
Review the complete filling and closure sequence
A useful syringe filling system specification follows each component and product contact from infeed to accepted discharge. It also states which steps are automatic, optional or supplied by the buyer.
1
Load syringes
Define bulk, grouped, tub-and-nest or another controlled presentation. GZB100 documentation lists grouped manual loading; automatic nest removal is a separate option.
2
Present product
Define the supply vessel, transfer path, temperature, mixing or heating need, hold-up and cleaning boundary before selecting the filling assembly.
3
Meter the fill
The four source documents list ceramic plunger-pump filling. Confirm the pump range, filling needle, fill profile and test method with the actual formulation.
4
Apply the closure
DZA machines feed and apply plastic caps. GZB machines use the confirmed stopper system and vacuum stoppering route. Define presence and position limits.
5
Inspect and discharge
State required checks, rejected-unit handling, data records and the physical handoff to rod insertion, labeling or secondary packaging.
Product and component trial
Send production-intent inputs
A photograph can start a discussion, but it cannot prove component handling or fill performance. The engineering review needs the nominated syringe and closure system together with the actual product or a justified representative medium.
- Syringe, cap or stopper drawings with critical tolerances
- Production samples from the intended supplier
- Product composition, viscosity or rheology and filling temperature
- Target dose, permitted variation and measurement method
- Enough material and components for setup and repeat trials
Product behavior
Match the dosing system to the formulation
“Liquid or ointment” is a starting category, not a complete filling specification. A pharmaceutical syringe filling machine must be reviewed against the actual material behavior and the permitted process window.
Flow and air release
State viscosity or rheology at filling temperature, foaming tendency, entrained air, settling and time-dependent behavior. These inputs affect the vessel, transfer path, pump range, needle and fill profile.
Fill range and accuracy
List every target dose. Define whether accuracy is assessed by mass or volume, the sample count, start-up treatment, calculation and acceptance limit. Do not treat the source-document percentage as a universal result.
Cleaning and changeover
Define product-contact materials, cleaning method, drainage, disassembly, changeover sequence and required evidence. Different products or dose ranges may require separate pump assemblies or format parts.
Visible-air requirement: vacuum filling does not justify an undefined “bubble-free” guarantee. State the inspection lighting or instrument method, sample condition, defect definition, permissible limit and sample quantity. Then challenge that requirement with the actual formulation during FAT.
Equipment and facility boundary
Define the base machine and every optional line module
The source documents describe modular equipment that can run as a standalone syringe filler or connect to other functions. Only modules named, engineered, priced and tested in the contract belong to the delivered line.
Infeed and denesting
Confirm manual grouped loading, automatic syringe feeding or automatic nest removal. Include tub opening, liner removal and transfer only when they are explicitly in scope.
Product preparation and supply
Define whether the buyer or supplier provides the vessel, stirring, heating, product transfer, level control and connection hardware. State the battery limit for utilities and cleaning.
Closure feeding
Plastic caps and elastomeric stoppers require different feeding and placement systems. Record closure orientation, replenishment, low-level handling, presence checks and rejects.
Local clean-air option
Optional laminar-flow hoods appear in the source documents. Airflow, filtration, monitoring, room integration and qualification must be defined for the specific project.
Rod insertion and labeling
Plunger-rod insertion, labeling, coding and label inspection are downstream options, not automatic inclusions in the base filling machine.
Secondary packaging
Define tray handling, blister packaging, cartoning, aggregation or case packing as separate interfaces with their own speeds, inspections and acceptance criteria.
Aseptic project responsibilities
If the search is for an aseptic syringe filling machine, the equipment is only one part of the control strategy. The URS must identify component preparation, product path, intervention design, environmental boundary, monitoring, cleaning, sterilization or decontamination responsibilities, alarms, data and site qualification.
- Separate equipment features from facility controls
- Name every customer and supplier responsibility
- Define DQ, IQ, OQ and PQ support by document and activity
- Agree FAT, SAT and open-item closure before shipment
Supplier comparison
How to compare syringe filling machine manufacturers
Compare evidence and project boundaries instead of company claims. Give every shortlisted manufacturer the same controlled inputs, then check whether the proposed machine, options and acceptance plan answer those inputs line by line.
Trace specifications to a model
Ask which document supports each capacity, size, accuracy, utility and material statement. Confirm that a value belongs to the offered model rather than another machine in the supplier’s range.
Compare the complete scope
Separate the base filler, format parts, product-supply equipment, closure handling, clean-air options, inspection, downstream modules, documentation and site activities. Record exclusions beside inclusions.
Compare the acceptance evidence
Require the same production-intent components, product condition, run duration, sampling plan and defect criteria. A demonstration video or short water run is not equivalent to an agreed FAT.
Also define how drawings, software or recipe revisions, spare and wear parts, manuals, training, remote support and open items will be controlled. These details influence lifecycle risk even when two quotations show a similar headline machine price.
Commercial scope
What changes syringe filling machine price?
A useful quotation is based on the complete process and acceptance boundary. A base-machine price cannot be compared fairly when another proposal includes additional formats, product preparation, clean-air equipment, inspection, documentation or downstream automation.
Machine platform
Plastic capping versus SCF glass vacuum stoppering and one versus two filling needles establish the first equipment boundary.
Formats and dose ranges
Additional syringe sizes, closures, molds, guides and pump assemblies change the mechanical and validation scope.
Product handling
Heating, mixing, level control, transfer, defoaming or special product-contact requirements must be defined and tested.
Automation
Automatic feeding, denesting, rod insertion, labeling, coding and secondary packaging add equipment and interfaces.
Inspection and records
Fill verification, visible-air inspection, closure checks, rejection, audit-trail or data-integration requirements affect design and testing.
Qualification and support
Document language, drawings, material records, FAT, SAT, qualification support, training and site services must be itemized.
For a comparable quote: ask every supplier to respond to the same URS, component set, format list, operating window and acceptance protocol. Current prices, commercial terms and delivery schedules belong in a dated formal quotation, not a permanent web-page promise.
Procurement evidence
Turn the syringe filling machine URS into a FAT protocol
The quotation, design review and factory acceptance test should use the same controlled inputs. This prevents a headline specification from becoming an acceptance dispute after the machine is built.
Send with the RFQ and URS
- Product description and production filling temperature
- Syringe, tub, nest, cap or stopper supplier and drawings
- All formats, target doses and planned batch profile
- Required accepted units per hour and permitted rejects
- Fill-accuracy calculation and sampling plan
- Visible-air, splash and closure-position limits
- Utilities, room interface and product-supply boundary
- Required documents, language and qualification support
Record during FAT
- Nominated product or justified representative medium
- Production-intent syringes and closures by lot
- Setup values and actual operating conditions
- Repeat fill study using the approved method
- Closure placement and defined defect challenges
- Normal run, stops, restarts and recovery actions
- Changeover and cleaning demonstration in scope
- Deviations, retained samples and signed open items
| Acceptance topic | Define before FAT | Evidence to record | Common ambiguity to remove |
|---|---|---|---|
| Output | Accepted units per hour, run duration, planned stops and reject rule | Total units, accepted units, rejects, stop log and operating time | Mechanical rate versus accepted production output |
| Fill amount | Target, tolerance, mass or volume method, sample size and calculation | Individual results, summary calculation, instruments and conditions | “Accuracy” without a measurement protocol |
| Visible air | Defect definition, lighting or instrument, sample condition and limit | Challenge samples, inspection results and deviations | Undefined “bubble-free” wording |
| Closure | Presence, position, insertion or capping criteria and reject response | Measured samples, defect challenge and rejection record | Visual appearance without an agreed limit |
| Recovery | Permitted operator interventions and restart checks | Alarm, stop, correction, line clearance and restart record | A successful uninterrupted short demonstration |
Buyer questions
Syringe filling machine FAQ
These answers separate published model references from the product, component and acceptance evidence still required for a project decision.
What is a syringe filling machine?
A syringe filling machine meters a defined product into a syringe and completes the specified closure step. In this HIJ range, DZA machines fill and cap nominated plastic syringes, while GZB machines fill and vacuum-stopper nominated SCF glass syringes.
Which HIJ machine fills plastic syringes?
HIJ-DZA100 is the one-needle plastic syringe filling and capping platform with a published capacity of 1,800–2,100 units per hour. HIJ-DZA200 uses two filling needles and lists 3,000–3,900 units per hour. Confirm the product, syringe, cap, dose range and accepted output before choosing.
Which HIJ machine fills SCF glass prefilled syringes?
HIJ-GZB100 is the one-needle vacuum filling and stoppering platform with a published capacity of 600–800 units per hour. HIJ-GZB200 uses two filling needles and lists 800–1,200 units per hour. Both require the exact syringe, nest or loading method, stopper and product trial.
Is a two-needle syringe filler always the better choice?
No. Two needles provide a higher published capacity within these model pairs, but selection also depends on dose, formulation behavior, component feeding, batch size, changeover, cleaning, accepted output and the FAT result.
Can one syringe filling machine run every syringe size?
No universal compatibility should be assumed. The product documents list model-specific size ranges, but individual syringes can require different molds, guides, feeders, closures and filling-pump assemblies. Put every planned format in the quotation and FAT scope.
Does vacuum filling guarantee a syringe with no visible air?
No. Product viscosity, entrained air, temperature, fill profile and inspection method affect the result. Define the visible-air defect, test conditions, sample quantity and acceptance limit, then verify it with the production formulation.
Can HIJ configure an aseptic syringe filling machine?
HIJ can review equipment features, optional local clean-air equipment and qualification-support documents against the buyer’s URS. Aseptic suitability and the validated state depend on the full process, facility, component preparation, environmental controls, procedures and site qualification; the machine alone does not establish them.
What information is needed for a syringe filling machine quotation?
Send the formulation and filling temperature, target doses, syringe and closure drawings, production samples, every format, accepted output, accuracy method, visible-air and closure limits, utilities, cleanroom interface, optional modules and required documentation.
Project inquiry
Get a syringe filling system configured around your components
Share your product, syringe, cap or stopper, fill range, accepted output, line boundary and FAT criteria. HIJ can review the four platforms and prepare an itemized technical scope for your project.