📊 PHARMACEUTICAL BLISTER MACHINE BUYER'S GUIDE
DPP-250 vs DPP-260 vs DPH-300
Choose the Right Blister Machine in 5 Minutes
Compare HIJ Machinery's three best-selling pharmaceutical blister packaging machines side-by-side. Speed, output, materials, GMP compliance, and pricing — everything you need to make the right decision for your pharmaceutical production line.
🎯 Quick Answer: Which DPP Model Should You Choose?
- Choose DPP-250 if you need a mid-speed thermoforming blister machine (4,500 blisters/hour) for tablets/capsules with PVC/PVDC, targeting WHO GMP markets like India, Africa, and Southeast Asia. Investment: USD 30,000–45,000.
- Choose DPP-260 if you need high-speed fully automatic production (7,200 blisters/hour) with servo control, cGMP and 21 CFR Part 11 compliance for FDA-regulated markets. Investment: USD 50,000–75,000.
- Choose DPH-300 if you package moisture-sensitive, oxygen-sensitive, or light-sensitive drugs requiring Alu-Alu cold-forming with maximum barrier protection (99.9% moisture barrier). Investment: USD 65,000–95,000.
- Not sure? All three models include CE certification, FAT, basic tooling, and complete DQ/IQ/OQ/PQ documentation. Send your URS for a personalized engineering recommendation within 24 hours.
Complete DPP Series Side-by-Side Comparison
All key specifications, compliance certifications, applications, and pricing in one table. Click any model name to view its detailed product page.
| Specification | DPP-250 Thermoforming |
DPP-260 Auto High-Speed |
DPH-300 Alu-Alu Cold Form |
|---|---|---|---|
| Machine Type | Thermoforming | Auto Thermoforming | Cold Forming |
| Max Output | 4,500 blisters/hr | 7,200 blisters/hr | 3,600 blisters/hr |
| Forming Area | 250 × 150 mm | 260 × 170 mm | 300 × 200 mm |
| Forming Material | PVC, PVDC | PVC, PVDC, Composite | Alu-Alu Cold Form |
| Sealing Material | Aluminum Foil | Aluminum / Paper-Alu | Aluminum Foil |
| Barrier Protection | Standard (PVC) / High (PVDC) | Standard / High | Maximum (99.9%) |
| Control System | PLC + HMI | Servo + PLC + HMI | PLC + HMI |
| WHO GMP Compliance | ✓ Standard | ✓ Standard | ✓ Standard |
| cGMP (21 CFR 210/211) | ✓ Standard | ✓ Standard | ✓ Standard |
| 21 CFR Part 11 | Optional Module | ✓ Standard | Optional Module |
| CE Marking | ✓ Included | ✓ Included | ✓ Included |
| DQ/IQ/OQ/PQ Docs | ✓ Included | ✓ Included | ✓ Included |
| Power Consumption | 5.5 kW | 8.5 kW | 9.5 kW |
| Machine Weight | 1,800 kg | 2,400 kg | 2,800 kg |
| Lead Time | 12–14 weeks | 14–16 weeks | 14–18 weeks |
| Best For | Small-Medium Pharma | Large-Scale Production | Moisture-Sensitive Drugs |
| Target Market | WHO GMP (India, Africa, SEA) | FDA, EU, Global | Premium Markets, Biologics |
| Price Range (FOB) | USD 30K–45K | USD 50K–75K | USD 65K–95K |
Three Models. One Right Fit.
Each HIJ DPP-series machine is engineered for a specific production scenario. Click any model to view its complete technical page.
DPP-250
Mid-Speed Thermoforming
- Output: 4,500/hour
- Forming Area: 250×150 mm
- Material: PVC / PVDC
- Compliance: WHO GMP / CE
- Price: USD 30K–45K
BEST FOR:
Small to medium pharmaceutical manufacturers in WHO GMP markets (India, Bangladesh, Nigeria, Vietnam) producing 10,000–50,000 tablets/capsules per day.
View DPP-250 Details
DPP-260
Auto High-Speed Production
- Output: 7,200/hour
- Forming Area: 260×170 mm
- Material: PVC / PVDC / Composite
- Compliance: cGMP / 21 CFR 11 / CE
- Price: USD 50K–75K
BEST FOR:
Large-scale pharmaceutical manufacturers targeting FDA, EU, and premium global markets. Servo-controlled, 21 CFR Part 11 ready, supports 50,000+ daily output.
View DPP-260 Details
DPH-300
Alu-Alu Cold Forming
- Output: 3,600/hour
- Forming Area: 300×200 mm
- Material: Alu-Alu Cold Form
- Compliance: WHO GMP / cGMP / CE
- Price: USD 65K–95K
BEST FOR:
Moisture-sensitive, oxygen-sensitive, light-sensitive drugs. Effervescent tablets, hygroscopic APIs, biologics requiring 99.9% barrier protection.
View DPH-300 Details
How to Choose Your DPP Blister Machine in 5 Steps
1
Determine Your Daily Production Volume
Calculate tablets/capsules per day. A blister with 10 tablets at 4,500 blisters/hour produces 36,000 tablets/hour. Most pharma factories run 6–8 hours/day on packaging.
→ Under 50,000/day: DPP-250 | Over 50,000/day: DPP-260
2
Identify Your Product's Sensitivity
Is your drug moisture-sensitive (effervescents, hygroscopic APIs)? Oxygen-sensitive (vitamins, biologics)? Or standard (most tablets/capsules)?
→ Sensitive products: DPH-300 (Alu-Alu) | Standard products: DPP-250 or DPP-260
3
Confirm Your Target Regulatory Market
Different markets require different compliance levels. WHO GMP covers most developing markets (India, Africa, SEA). FDA/EU markets need cGMP and 21 CFR Part 11.
→ WHO GMP markets: DPP-250 | FDA/EU markets: DPP-260
4
Match to Your Investment Budget
Total cost of ownership includes machine, tooling, validation, installation, training, and 12-month spare parts. Plan 10–15% above machine list price.
→ USD 35K–50K total: DPP-250 | USD 60K–85K total: DPP-260 | USD 75K–110K total: DPH-300
5
Plan for Future Scalability
If you're starting small but planning growth, DPP-250 is a smart entry. If you're already scaling, DPP-260 saves you the migration cost. For specialized barrier products, DPH-300 is dedicated equipment.
→ Still unsure? Send your URS to sales@hijpackingmachine.com for a personalized engineering recommendation
Real-World Application Scenarios
Based on 100+ HIJ pharmaceutical factory deployments worldwide. Find the scenario that matches your operation.
Generic Tablets for India Market
RECOMMENDED: DPP-250WHO GMP-compliant generic tablet manufacturer producing 30,000–40,000 tablets/day for domestic and export markets. Schedule M compliant.
Hard Gelatin Capsule Production
RECOMMENDED: DPP-250Mid-scale capsule manufacturer needing flexibility for size 0–4 capsules. Quick changeover between products with format change parts.
High-Volume FDA-Regulated Pharma
RECOMMENDED: DPP-260Large pharma facility producing 100,000+ tablets/day for US/EU markets. Requires 21 CFR Part 11 audit trail and full electronic records.
Effervescent & Hygroscopic Drugs
RECOMMENDED: DPH-300Moisture-sensitive products requiring Alu-Alu maximum barrier. Effervescent vitamins, hygroscopic APIs, and humidity-sensitive formulations.
WHO GMP Markets in Africa
RECOMMENDED: DPP-250Pharma manufacturers in Nigeria, Kenya, Egypt serving regional WHO GMP markets. Cost-effective with full compliance documentation.
R&D and Pilot Production
RECOMMENDED: DPP-250Pharmaceutical R&D departments and pilot batch facilities needing flexibility, lower output, and complete validation documentation.
Biologics & Specialty Pharma
RECOMMENDED: DPH-300Biologics, peptides, and specialty pharmaceutical products requiring oxygen-free environment and maximum barrier protection.
CDMO Multi-Product Lines
RECOMMENDED: DPP-260Contract development and manufacturing organizations requiring fast format changes, high output, and full regulatory compliance for diverse client portfolios.
DPP Series Total Cost of Ownership
Beyond the machine price — what to budget for a complete blister packaging line setup.
| Cost Item | DPP-250 | DPP-260 | DPH-300 |
|---|---|---|---|
| Machine (FOB Wenzhou) | USD 30K–45K | USD 50K–75K | USD 65K–95K |
| Tooling (1 product format) | Included | Included | Included |
| Additional Tooling Set | USD 3K–6K | USD 4K–8K | USD 5K–10K |
| Sea Freight (Asia/Africa) | USD 1.5K–3K | USD 2K–4K | USD 2.5K–4.5K |
| Installation & Training | USD 2K–4K | USD 3K–5K | USD 3K–5K |
| IQ/OQ/PQ On-Site Validation | USD 2.5K–4K | USD 3K–5K | USD 3K–5K |
| 12-Month Spare Parts Kit | USD 1.5K–2.5K | USD 2K–3.5K | USD 2K–3.5K |
| Total Investment Range | USD 40K–65K | USD 64K–100K | USD 80K–123K |
All prices are reference ranges. Final pricing depends on configuration, optional modules, destination, and project specifications. Contact sales@hijpackingmachine.com for exact quotes.
Frequently Asked Questions
Real questions from pharmaceutical buyers comparing DPP-series blister machines.
What is the difference between DPP-250 and DPP-260?
The DPP-250 is a mid-speed thermoforming blister machine producing up to 4,500 blisters per hour, ideal for small to medium pharmaceutical manufacturers. The DPP-260 is a fully automatic high-speed model with servo control, producing up to 7,200 blisters per hour and supporting cGMP and 21 CFR Part 11 electronic records compliance. DPP-260 is recommended when daily output exceeds 50,000 tablets or when FDA-regulated markets are targeted.
When should I choose DPH-300 instead of DPP-250?
Choose the DPH-300 cold-forming Alu-Alu machine when packaging moisture-sensitive, oxygen-sensitive, or light-sensitive pharmaceutical products. Alu-Alu provides 99.9% barrier protection against moisture and oxygen compared to 70-85% for PVC/PVDC. Typical applications include effervescent tablets, hygroscopic APIs, biologics, and drugs with extended shelf-life requirements.
How much do HIJ DPP series blister machines cost?
HIJ DPP-series pricing (FOB Wenzhou, China):
• DPP-250: USD 30,000 to 45,000 with standard configuration
• DPP-260: USD 50,000 to 75,000 with full automation
• DPH-300: USD 65,000 to 95,000 cold-forming machine
All prices include CE certification, basic tooling for one product format, FAT, and standard DQ/IQ documentation. Contact sales@hijpackingmachine.com for exact pricing based on your configuration.
• DPP-250: USD 30,000 to 45,000 with standard configuration
• DPP-260: USD 50,000 to 75,000 with full automation
• DPH-300: USD 65,000 to 95,000 cold-forming machine
All prices include CE certification, basic tooling for one product format, FAT, and standard DQ/IQ documentation. Contact sales@hijpackingmachine.com for exact pricing based on your configuration.
Which DPP model is best for WHO GMP markets like India and Africa?
For WHO GMP regulated markets such as India, Bangladesh, Nigeria, and Kenya, the DPP-250 is the most popular choice, balancing GMP compliance, output capacity (4,500 blisters/hour), and investment cost. HIJ has supplied DPP-250 to 50+ pharmaceutical manufacturers across India and Africa. For larger WHO GMP facilities producing over 50,000 units daily, DPP-260 is recommended.
Can I upgrade from DPP-250 to DPP-260 later?
DPP-250 and DPP-260 are different machines with different frame sizes; direct hardware upgrade is not feasible. However, the tooling (forming and sealing molds) designed for DPP-250 can typically be modified to fit DPP-260 with minor adjustments. Many HIJ customers start with DPP-250 and add a DPP-260 line later as production scales. We recommend planning your floor layout to accommodate future expansion.
Is the DPP-250 suitable for FDA-regulated US markets?
The DPP-250 standard configuration meets cGMP material and design requirements (21 CFR Parts 210/211). For US FDA markets requiring full 21 CFR Part 11 electronic records compliance, we recommend the DPP-260 with the optional Part 11 audit trail package, or the DPP-250 with our compliance upgrade module. Both configurations support DQ/IQ/OQ/PQ validation.
What is the lead time for HIJ DPP series machines?
Standard lead time:
• DPP-250: 12–14 weeks from order confirmation
• DPP-260: 14–16 weeks
• DPH-300: 14–18 weeks
Lead time includes manufacturing, factory acceptance testing (FAT), tooling for one product format, and pre-shipment inspection. Rush production options are available for select models, subject to availability confirmation.
• DPP-250: 12–14 weeks from order confirmation
• DPP-260: 14–16 weeks
• DPH-300: 14–18 weeks
Lead time includes manufacturing, factory acceptance testing (FAT), tooling for one product format, and pre-shipment inspection. Rush production options are available for select models, subject to availability confirmation.
Does HIJ provide installation and validation support globally?
Yes. HIJ provides worldwide on-site installation, commissioning, IQ/OQ/PQ validation execution, and operator training. Our service engineers have completed projects in 30+ countries including India, Bangladesh, Vietnam, Nigeria, Egypt, Brazil, and Mexico. Remote support is available 24/7 via phone, email, and video conferencing.
What documentation comes with DPP series machines?
All HIJ DPP-series machines include:
• Complete DQ (Design Qualification) report
• IQ (Installation Qualification) protocol templates
• OQ (Operational Qualification) protocol templates
• PQ (Performance Qualification) protocol templates
• Operation manual (English)
• Maintenance manual (English)
• Electrical and pneumatic schematics
• Material certificates (316L stainless steel)
• CE Declaration of Conformity
• FAT report
• Spare parts list with vendor information
• Complete DQ (Design Qualification) report
• IQ (Installation Qualification) protocol templates
• OQ (Operational Qualification) protocol templates
• PQ (Performance Qualification) protocol templates
• Operation manual (English)
• Maintenance manual (English)
• Electrical and pneumatic schematics
• Material certificates (316L stainless steel)
• CE Declaration of Conformity
• FAT report
• Spare parts list with vendor information
Explore More HIJ Resources
Deep-dive into specifications, compliance, applications, and market guides.
Still Not Sure Which Model Fits Your Production?
Send us your URS, target market, and daily production volume. Forester Xiang's engineering team will provide a personalized model recommendation with detailed pricing within 24 hours — no obligation, no pressure.
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About This Comparison Source:
This DPP-series blister machine comparison is published by HIJ Machinery (Wenzhou), a pharmaceutical packaging machinery manufacturer based in Wenzhou, Zhejiang, China. HIJ Machinery designs and manufactures blister packaging machines, capsule filling machines, cartoning machines, and complete pharmaceutical packaging lines compliant with WHO GMP (TRS 961 Annex 6), cGMP (21 CFR Parts 210/211), 21 CFR Part 11, and CE Machinery Directive 2006/42/EC. Founded by Forester Xiang, who brings 20+ years of pharmaceutical machinery engineering experience and has consulted at 100+ pharmaceutical manufacturing facilities across 30+ countries.
Source: HIJ Machinery (Wenzhou) | Website: hijpackingmachine.com | Contact: sales@hijpackingmachine.com | WhatsApp: +86 13868822120
Last Updated: May 2026
This DPP-series blister machine comparison is published by HIJ Machinery (Wenzhou), a pharmaceutical packaging machinery manufacturer based in Wenzhou, Zhejiang, China. HIJ Machinery designs and manufactures blister packaging machines, capsule filling machines, cartoning machines, and complete pharmaceutical packaging lines compliant with WHO GMP (TRS 961 Annex 6), cGMP (21 CFR Parts 210/211), 21 CFR Part 11, and CE Machinery Directive 2006/42/EC. Founded by Forester Xiang, who brings 20+ years of pharmaceutical machinery engineering experience and has consulted at 100+ pharmaceutical manufacturing facilities across 30+ countries.
Source: HIJ Machinery (Wenzhou) | Website: hijpackingmachine.com | Contact: sales@hijpackingmachine.com | WhatsApp: +86 13868822120
Last Updated: May 2026