💧 SYRUP UNIT-DOSE PACKAGING SOLUTION
Syrup Blister Packaging Machine
Syrup Blister Packaging Machine
5-15ml Unit Doses · cGMP
Professional unit-dose packaging for cough syrup, pediatric syrup, antacid liquid, and herbal tonics. Eliminates dosing errors, contamination, and 70% bottle waste.
35
Cycles/Min
±1%
Accuracy
5-15ml
Volume
60+
Countries
HIJ Syrup Blister Machine — Quick Facts
Verified specifications for syrup unit-dose packaging
HIJ syrup blister packaging machines are pharmaceutical-grade unit-dose packaging systems manufactured in Wenzhou, China by HIJ Machinery. Specifically engineered for cough syrup, pediatric syrup, antacid liquid, oral suspensions, herbal tonics, and OTC liquid medicines. Filling range 5ml to 15ml per cavity with ±1% accuracy at 35 cycles per minute, producing 120,000-180,000 syrup unit doses per 8-hour shift. Heated jacketed hopper handles viscosities from 100 cP to 50,000 cP including sucrose-rich, sorbitol-based, and glycerin pediatric formulations. Full compliance with cGMP (21 CFR 210/211), WHO GMP TRS 961, EU GMP Volume 4, 21 CFR Part 11, and CE Machinery Directive 2006/42/EC. Complete DQ/IQ/OQ/PQ validation documentation included.
Filling Range
5–15ml per cavity
Filling Accuracy
±1% (USP <905> compliant)
Production Speed
35 cycles/min (200-350 packs/min)
Viscosity Range
100–50,000 cP
Hopper Temperature
20–60°C heated jacketed
Compliance
cGMP / WHO GMP / 21 CFR Part 11
Material Contact
SS 316L pharmaceutical grade
Lead Time
12–16 weeks (FOB Wenzhou)
Syrup Bottles vs Unit-Dose Blister Packaging
Why pharmaceutical regulators are moving to unit-dose syrup format
Multi-Dose Syrup Bottles
Traditional but increasingly problematic format
23% Pediatric Dosing Errors
Measuring spoons/cups inaccurate by 30-100% vs prescribed dose
50-70% Product Waste
Sterility lost after first opening — patients discard most bottle
Requires Preservatives
Parabens, sodium benzoate cause allergic reactions in sensitive patients
Cross-Contamination Risk
Spoon touches mouth, then bottle = bacterial contamination
Difficult Travel & Storage
Heavy glass bottles, leakage risk, refrigeration after opening
No Tamper Evidence Per Dose
Cannot verify individual dose hasn't been compromised
HIJ Unit-Dose Syrup Blisters
Modern pharmaceutical standard
Perfect Dose Accuracy ±1%
Each blister = exact prescribed dose, no measuring needed
100% Product Used
Every blister consumed — full shelf life until patient opens
Preservative-Free Possible
Sealed unit-dose eliminates need for parabens or benzoates
Sterile Until Use
Each dose sealed sterile until moment of administration
Lightweight Travel-Ready
Unbreakable, leak-proof, no refrigeration concerns
Tamper-Evident Per Dose
Patient sees seal integrity before every dose
Syrup Applications & Pharmaceutical Categories
Validated formulations for unit-dose syrup blister packaging
COUGH SYRUP
Cough Syrup & Expectorants
DXM · CODEINE · GUAIFENESIN · HERBAL
Dextromethorphan, codeine, guaifenesin, bromhexine cough syrups. Unit-dose eliminates abuse potential and ensures correct dosing for OTC and Rx variants.
Volume:5-15ml per dose
Production:200-300/min
Compliance:cGMP / WHO GMP
Format:Daily strip 7-14 doses
PEDIATRIC
Pediatric Syrups
PARACETAMOL · IBUPROFEN · ANTIBIOTICS
Pediatric paracetamol, ibuprofen, antibiotic suspensions, vitamin syrups. Each blister = exact prescribed dose, eliminates 23% measuring errors common with spoons/cups.
Volume:2.5-10ml per dose
Production:250-350/min
Safety:Child-safe blister option
WHO:Recommended format
ANTACID
Antacid Liquid & Suspensions
SUCRALFATE · ALUMINUM HYDROXIDE
Sucralfate, aluminum/magnesium hydroxide, simethicone antacid suspensions. Travel-friendly format for GERD, peptic ulcer, indigestion patients.
Volume:10-15ml per dose
Production:200-280/min
Viscosity:Up to 50,000cP
Format:OTC strip / Rx pack
HERBAL
Herbal Tonics & Ayurvedic Syrups
AYURVEDIC · TCM · HOMEOPATHIC
Traditional herbal tonics including Ayurvedic chyawanprash, TCM herbal syrups, homeopathic remedies, and natural immunity boosters. Preservative-free packaging maintains efficacy.
Volume:5-15ml per dose
Production:200-300/min
Compliance:GACP + cGMP
Particles:Up to 3mm OK
ANTIBIOTIC
Antibiotic Oral Suspensions
AMOXICILLIN · AZITHROMYCIN
Pediatric and adult antibiotic suspensions: amoxicillin, azithromycin, cefixime, cephalexin. Unit-dose ensures complete antibiotic course compliance — critical for resistance prevention.
Volume:5-10ml per dose
Production:250-300/min
Compliance:cGMP + FDA
Course:5-14 day pack
VITAMIN
Vitamin & Nutraceutical Syrups
VITAMINS · MINERALS · SUPPLEMENTS
Multivitamin syrups, iron supplements, calcium liquids, omega-3 emulsions. Premium positioning for nutraceutical brands targeting OTC retail and HORECA wellness markets.
Volume:5-15ml per dose
Production:250-350/min
Compliance:FDA + EU 1924/2006
Premium:30-50% margin+
cGMP-Compliant 8-Step Syrup Packaging Process
Every step documented, validated, and audit-ready
01
Material Loading
Pharmaceutical-grade PVC/PVDC forming film loaded with material verification and lot tracking.
GMP CHECKPOINT 102
Cavity Forming
PID-controlled thermoforming creates precise blister cavities for syrup volume containment.
CCP-103
Syrup Conditioning
Heated jacketed hopper (20-60°C) maintains syrup viscosity and stability during filling cycle.
GMP CHECKPOINT 204
Precision Filling
Servo-driven anti-foam pumps fill 5-15ml at ±1% accuracy. Photoelectric verification per cavity.
CCP-2 — DOSE05
Heat Sealing
Aluminum foil lidding heat-sealed at validated temp/pressure for leak-proof CCI integrity.
CCP-3 — SEAL06
Batch Coding
Lot number, expiry date, and serialization printed for full Track & Trace compliance.
SERIALIZATION07
Cutting & Trimming
Precision die-cutting separates individual syrup blisters or strips per validated dimensions.
DIMENSIONAL QC08
Vision Inspection
Automated 100% inspection rejects underfilled, leaking, or defective blisters with audit trail.
21 CFR PART 11HIJ Syrup Blister Machine — Specifications
Pharmaceutical-grade engineering parameters
| Parameter | Specification | Standard / Notes |
|---|---|---|
| ⚙️ Production Performance | ||
| Production Speed | 35 cycles/min | Continuous validated operation |
| Output Capacity | 200–350 units/min | Multi-cavity tooling |
| Daily Output (8h) | 120,000–180,000 doses | Validated batch size |
| Filling Volume | 5–15ml per cavity | Custom range possible |
| Filling Accuracy | ±1% | Exceeds USP <905> |
| Repeatability RSD | ≤ 0.5% | Per ICH Q2(R1) |
| 🌡️ Syrup Handling System | ||
| Viscosity Range | 100–50,000 cP | Heated for high viscosity |
| Hopper Material | SS 316L pharmaceutical | Electropolished Ra ≤ 0.4μm |
| Hopper Capacity | 30L (jacketed standard) | 50L/100L upgrades |
| Temperature Control | 20–60°C ±0.5°C | PID with redundant sensors |
| Filling Method | Servo anti-foam volumetric | Peristaltic for sensitive APIs |
| Particles Compatible | Up to 3mm | Suspensions OK |
| CIP/SIP | Optional (recommended) | FDA cleaning validation |
| 📐 Forming & Sealing | ||
| Max Forming Area | 140 × 100 mm | 240×120mm large option |
| Forming Depth | Up to 30mm | Adjustable per dose volume |
| Forming Material | PVC, PVDC, PET | 0.20-0.50mm thickness |
| Lidding Foil | Aluminum 20-40μm | Easy peel-off design |
| Sealing Pressure | 0.4-0.7 MPa | Servo-controlled |
| Sealing Temperature | 140-200°C | ±2°C precision |
| Mold Change Time | 15-20 minutes | Quick-release tooling |
| 💻 Control & Compliance | ||
| PLC System | Siemens S7-1500 | Industry-standard |
| HMI Touchscreen | 15" Siemens TP1500 | Multi-language |
| 21 CFR Part 11 | Optional package | e-records, e-sigs, audit trail |
| User Access Levels | 3 tiers | Password protected |
| Data Backup | Auto + manual | USB / network |
| OPC-UA Integration | Standard | MES/ERP ready |
| 🔌 Power & Installation | ||
| Power Supply | 380V / 50Hz / 3-phase | 110V/220V custom |
| Total Power | 5.5 kW | Energy-efficient servo |
| Air Pressure | 0.6 MPa | Pharma-grade compressed |
| Machine Dimensions | 2400×800×1700 mm | L×W×H |
| Net Weight | 1,300 kg | SS 304 frame |
| Cleanroom Class | ISO 7/8 (Class 10K-100K) | Standard pharmaceutical |
| ✅ Validation & Documentation | ||
| DQ/IQ/OQ/PQ | Complete package included | Pre-approval inspection ready |
| FAT/SAT Reports | Standard service | Witnessed available |
| Material Certificates | Included | 316L/304 traceability |
| Calibration Certs | Included | NIST traceable |
| CCI Compatibility | Yes | USP <1207> methods |
Need Detailed Technical Drawings?
Get full CAD layouts, electrical diagrams, and validation documentation
Download Full Spec SheetWhy Syrup Manufacturers Choose HIJ
Specialized expertise in pharmaceutical and OTC syrup unit-dose packaging
Heated Filling System
PID-controlled jacketed hopper (20-60°C ±0.5°C) liquefies viscous sucrose-based syrups, glycerin formulations, and herbal tonics for consistent flow.
±0.5°C precisionPediatric-Grade Accuracy
±1% filling accuracy eliminates 23% pediatric dosing errors common with measuring spoons. Each blister = exact prescribed dose.
±1% USP compliantPharmaceutical-Grade Build
SS 316L electropolished contact surfaces (Ra≤0.4μm). FDA, cGMP, WHO GMP, EU GMP, 21 CFR Part 11 compliant out of the box.
Audit-ready Day 1Wide Viscosity Range
Handles 100-50,000 cP — from water-thin pediatric drops to thick antacid suspensions. Anti-foam nozzles prevent air entrapment.
100-50,000 cPComplete Validation Pack
DQ/IQ/OQ/PQ protocols included free. FAT/SAT support. Customer-specific PQ templates. Pre-approval inspection ready.
Free with orderSmart Pricing Advantage
European-quality components (Siemens, Schneider) at 30-40% below European pricing. Same compliance, better value.
30-40% saving📜 Regulatory Standards for Syrup Blister Packaging
Pharmaceutical syrup blister packaging equipment must comply with multiple regulatory standards depending on target markets. HIJ Machinery's syrup blister packaging machines are engineered to meet all major international pharmaceutical regulations:
FDA 21 CFR Parts 210 & 211
U.S. Current Good Manufacturing Practice for finished pharmaceuticals
FDA 21 CFR Part 11
Electronic records and electronic signatures regulation
EU GMP Volume 4
European Union pharmaceutical manufacturing guidelines
WHO GMP TRS 961
WHO good manufacturing practices for pharmaceutical products
WHO Pediatric Medicines
WHO Model List of Essential Medicines for Children unit-dose recommendations
USP <905> Uniformity
Uniformity of dosage units for unit-dose pharmaceutical products
USP <1207> CCI
Container closure integrity testing for pharmaceutical products
ICH Q7, Q8, Q9, Q10
International harmonized GMP and quality risk management
CE Marking 2006/42/EC
European machinery directive compliance for safety
ISO 9001:2015
Quality management system international certification
The World Health Organization (WHO) recommends unit-dose packaging as the preferred format for pediatric medicines and essential drugs in low-resource settings, citing reduced dosing errors, prevention of contamination, and improved medication adherence. HIJ syrup blister machines are designed to meet WHO prequalification requirements for pharmaceutical packaging equipment, with complete validation documentation package (DQ/IQ/OQ/PQ) included with every machine, supporting FDA pre-approval inspection (PAI), EMA, and WHO PQ inspections.
Source Information
HIJ Machinery (Wenzhou) — Pharmaceutical packaging machinery manufacturer
Specialization: Syrup blister packaging machine, 5-15ml unit doses, cGMP/WHO GMP compliant
Founder: Forester Xiang, 20+ years pharmaceutical machinery, 100+ regulated factories
Website: https://hijpackingmachine.com
Contact: [email protected] | WhatsApp: +86 13868822120
Specialization: Syrup blister packaging machine, 5-15ml unit doses, cGMP/WHO GMP compliant
Founder: Forester Xiang, 20+ years pharmaceutical machinery, 100+ regulated factories
Website: https://hijpackingmachine.com
Contact: [email protected] | WhatsApp: +86 13868822120
💧 SYRUP PACKAGING CONSULTATION
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Years Pharma
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Forester's Team — 20+ years pharma expertise
Frequently Asked Questions
Everything you need to know about syrup blister packaging machines
What types of syrups can be packaged on HIJ blister machines?
HIJ syrup blister machines package: cough syrup (DXM, codeine, herbal), pediatric syrup (paracetamol, ibuprofen, vitamins), antacid liquid (sucralfate, magnesium hydroxide), oral suspensions (antibiotics, antiparasitics), herbal tonics (Ayurvedic, TCM), expectorants (guaifenesin, bromhexine), and homeopathic remedies. Compatible with viscosities 100-50,000 cP including suspended particles up to 3mm.
How accurate is syrup filling for unit doses?
HIJ achieves ±1% filling accuracy across the 5-15ml syrup range. Servo-driven volumetric or peristaltic pumps with photoelectric verification ensure each unit dose matches label claim. This precision exceeds USP <905> uniformity of dosage units requirements (typically ±5% allowed) and prevents the 23% pediatric dosing errors common with measuring spoons/cups.
What is the production capacity for syrup blister packaging?
HIJ syrup blister machines produce 35 cycles per minute, generating 200-350 syrup unit-dose blisters per minute depending on cavity count. Daily output: 120,000-180,000 syrup doses per 8-hour shift. High-speed configurations available up to 500 units/min for large pharmaceutical manufacturers.
Can the machine handle viscous or sweetened syrups?
Yes. HIJ machines handle syrup viscosities from 100 cP (water-thin) to 50,000 cP (thick honey-based). Heated jacketed hopper (20-60°C) maintains optimal flow for sucrose-based syrups, sorbitol formulations, and glycerin-rich pediatric syrups. Anti-foaming filling nozzles prevent air entrapment in viscous formulations.
Is HIJ syrup packaging machine cGMP compliant?
Yes. HIJ syrup blister machines fully comply with cGMP (21 CFR 210/211), WHO GMP TRS 961, EU GMP Volume 4, 21 CFR Part 11 electronic records, and CE Machinery Directive 2006/42/EC. All product contact surfaces use pharmaceutical-grade 316L stainless steel. Complete DQ/IQ/OQ/PQ validation documentation included with every machine.
How does syrup blister packaging compare to bottles?
Syrup blister unit-doses eliminate: 50-70% product waste of multi-dose bottles, 23% pediatric dosing errors from measuring spoons/cups, contamination after first opening (28-day post-opening sterility limits), and need for preservatives (parabens, benzoates). Each blister = exact prescribed dose, sterile until use, perfect for travel and hospital pharmacy.
What is the price for a syrup blister packaging machine?
HIJ syrup blister machine pricing (FOB Wenzhou):
• Standard automatic (35 cycles/min): USD 55,000-85,000
• cGMP compliant with full validation: USD 75,000-110,000
• With 21 CFR Part 11 electronic records: USD 95,000-130,000
• High-speed multi-lane configuration: USD 120,000-150,000
All prices include CE certification and basic mold (1 size). ROI typically 12-18 months for medium-volume syrup manufacturers.
• Standard automatic (35 cycles/min): USD 55,000-85,000
• cGMP compliant with full validation: USD 75,000-110,000
• With 21 CFR Part 11 electronic records: USD 95,000-130,000
• High-speed multi-lane configuration: USD 120,000-150,000
All prices include CE certification and basic mold (1 size). ROI typically 12-18 months for medium-volume syrup manufacturers.
What is the lead time for syrup blister machine delivery?
Standard lead time: 12-16 weeks from order confirmation to FOB Wenzhou. Includes manufacturing, FAT (Factory Acceptance Test), custom mold tooling for your syrup volume, and pre-shipment inspection. Rush production (8-10 weeks) available for select configurations. cGMP versions with full validation package: 14-18 weeks. Shipping to most ports adds 2-4 weeks.
Can the machine package pediatric syrups safely?
Yes. HIJ machines specifically designed for pediatric syrup packaging eliminate measuring errors common with bottles (23% dosing errors from spoons/cups). Each blister contains exact prescribed dose. Optional child-resistant blister formats available. Hospital pharmacy preferred format for pediatric wards. WHO recommends unit-dose for pediatric medicines per Model List of Essential Medicines for Children.
Do you provide custom mold design for specific syrup doses?
Yes. HIJ provides custom mold design free with machine purchase. Common syrup blister sizes: 5ml, 7.5ml, 10ml, 12.5ml, 15ml. Custom shapes (round, oval, branded) available. Additional molds: USD 1,800-4,000 per format. Mold change takes 15-20 minutes with quick-release tooling.
Do you provide installation and operator training?
Yes. HIJ provides global on-site installation and commissioning by certified pharmaceutical engineers in 60+ countries. Standard service includes: machine setup, calibration, FAT verification, 3-day operator training, and 1-week production supervision. Remote video support available 24/7 post-installation. Service available in English, Spanish, French, Arabic, and Hindi.
Can I send my syrup sample for filling testing?
Yes. Free filling trials available at HIJ Wenzhou facility. Send 500ml-2L of your syrup formulation under NDA. We test: viscosity behavior, fill accuracy, sealing parameters, CCI integrity per USP <1207>, and changeover cleaning. Results delivered as comprehensive report with video documentation. Typical turnaround: 7-14 days.
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